Homocysteine Cardiovascular

Homocysteine cardiovascular disease is in fact the underlying cause of many vascular illnesses. You do not have to be an organic-chemistry major to find value in this page.

Why is this substance so implicated in a host of sicknesses? This page could equally easily be named after stroke, Parkinson's disease and many other illnesses such as osteoporosis caused by this naturally-formed but toxic byproduct of protein metabolism.

It is a naturally-occurring intermediate that is formed in the body from the breakdown of methionine which is rich in many foods that we eat on a daily basis; dairy, fish and meat, seeds and grains too.

What is homocysteine?

This page was last updated by Bernard Preston on 13th November, 2019.

Methionine is deficient in legumes so in our hummus recipe, for example, we boost its content by the addition of a sesame-seed paste called tahini. It is an essential amino acid in protein metabolism; a deficiency causes a very serious disease called kwashiorkor.

No human can survive without methionine from their food.

Vegetarians and vegans must balance their proteins to ensure that they contain all the essential amino-acids. On the plus side they tend to eat plenty of the foods rich in the vitamins and minerals needed for methionine metabolism; they just have to make sure they get enough of it.

In normal metabolism, homocysteine is immediately converted in the body into two very important substances.

1. GLUTATHIONE is a very powerful anti-oxidant and detoxifying chemical in the body; it prevents premature aging

  • It keeps you young and slows the aging process of your body. But for this to happen, we require high levels of zinc, and vitamins B2 and B6. Without them the enzymes that convert homocysteine to glutathione are inhibited, and the concentration of this toxic methionine-intermediate in the blood rises.

2. SAMe is a powerful anti-arthritic chemical in the body; and it helps prevent depression. It is involved in the production of the neurotransmitters in the brain; the chemicals involved in mood, for example, and memory, and how well you sleep.

  • But the conversion of toxic HOMOCYSTEINE to SAMe by enzymes requires adequate vitamin B2, B12 and Folate (B9); and zinc. If these co-factors are not present in adequate quantities, yes, you guessed it, the homocysteine in the blood increases; that is indeed bad.


Whenever the scientific community comes across a treatment that claims to be able to cure everything in the body from acne to athlete's foot, it becomes very skeptical. As a result the discoverer of the toxic-effect of homocysteine was for decades left out in the medical wilderness.

Copy and paste "The H factor" into this search engine for more information.

Homocysteine Cardiovascular

The authors of the H-factor claim that high homocysteine levels in the blood is one of the main causes of cardiovascular disease, Alzheimer's and metastatic tumours; and strokes, arthritis and more than 50 illnesses in all.

Frankly I was skeptical too; until I discovered there are now over 200 research articles in highly-respected scientific journals confirming the toxic effect of high levels of homocysteine in the blood.

Here is an example; writing in the New England journal[1] of medicine, researchers describe the association between homocysteine and narrowing of the carotid. Arterial-stenosis means not enough blood can get through, in this case to the brain. 

High levels of LDL cholesterol, low-density lipoprotein, is very dangerous in the body; it is beyond dispute.

But high levels of homocysteine change the LDL into an even more dangerous form called oxidised cholesterol. This substance attacks the intima, the innermost layer of arteries, causing atherosclerosis. These walls then harden and thicken and macrophages begin to stick to them.

Furthermore high levels of homocysteine makes the blood clot more readily than normal. The overall result is not enough oxygen to the brain, and all organs, of course, and a high risk of stroke and cardiovascular-disease.

In short like diabetes and smoking, high homocysteine levels cause arterial disease, and that means that every tissue in your body is under threat; acne to athlete's foot, baldness to ingrowing-toenails.

Why on this website?

There are several reasons. The first that comes to mind is that it is now proven that persons suffering from atherosclerosis will also experience more lower back-pain. Moreover they respond more slowly to all forms of treatment, simply because the lumbar plexus of arteries are blocked. Less blood means slower healing.

Secondly whilst ours is a relatively safe profession and serious iatrogenic-illness events are very rare, patients with raised homocysteine and the associated atherosclerosis must be amongst the higher risk group.

Copy and paste "Atherosclerosis symptoms low back pain" into this search engine for more information.

Metastatic disease

In tumours the cell's DNA is damaged in some way. Most scientists are leaning towards excessive oxidation by free-radicals as the main cause of this alteration of the genes.

The result is uncontrolled proliferation by the damaged DNA of the tissue affected; we are prone to profound metastatic disease.

GLUTATHIONE is one of the most powerful anti-oxidants in the body.

Not enough zinc and B vitamins > drop in the conversion of HOMOCYSTEINE to GLUTATHIONE > double-disaster:

Low Gluthathione, the body's chief anti-oxidant means raised homocysteine, and consequent destruction of the intima of your arteries. You become seriously sick.


Diabetes type 2 is intimately involved with homocysteine cardiovascular illnesses, as are many other diseases.

Parkinson's disease, Alzheimer's and depression

Poor homocysteine metabolism has huge repercussions in the body, affecting every tissue and organ.

Healthy homocysteine metabolism means you have a normal cadiovascular profile, and likewise for all the other fifty-plus illnesses.

This is a vast-subject. Far too big for this page; too big for a whole website, in fact.

If concerned, get tested. It is a simple blood test.

Are you concerned about your HOMOCYSTEINE CARDIOVASCULAR profile?


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Homocysteine and osteoporosis

Research done on a large group of people from the Framingham Study found that men had four-times the risk of hip fracture, and women 190pc increase if they had raised homocysteine.

Their conclusion was that the homocysteine concentration in the blood, which is easily modifiable by simple dietary intervention, is an important risk-factor for hip fracture in the older person.[2]

Researchers propose that raised homocyteine interferes with the cross-linking of collagen in bone, without actually affecting the density. This confirms the belief that our hips and vertebrae can be weak without being osteoporotic.

The H factor is a great read

Benefits of folate

The benefits of folate go far beyond homocysteine cardiovascular disease; just the prevention of spina-bifida is a good enough reason to enjoy your greens daily. Just look at the lettuce nutritional value.

TREATMENT of Homocysteine Cardiovascular

Being a writer myself, I am not going to cheat Dr James Braly and Patrick Holford of their paltry few cents that publishers pay authors for all their grind. Buy their book; it makes  for compelling and easy reading. Profound yet light.

In short if you are eating foods rich in the anti-oxidants, all the coloured fruits and salads, and almonds, then you are half way there. If uncertain take a multivitamin and mineral, rich in the B vitamins and zinc and you are 80% sure of avoiding homocysteine cardiovascular-disease. For the rest, read the book.

A poached egg on a bed of spinach.


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